Enhancer-derived RNA (eRNA) is a large class of non-coding RNA transcribed from the region of the active enhancer. Previous studies have been shown that eRNA play important roles in diverse biological processes by mediating the activation of target genes. However, the systematic landscape of eRNAs during mammalian early embryo development remains elusive.To explore eRNA profiles and regulation, we constructed a Map of Enhancer Expression During Mouse Early Embryo Development (M2ED²)

 

In M2ED², users can:

(1) Query the eRNA expression profile across multiple developmental stages of mouse early embryos.

(2) Query transcription factors that activate eRNA expression across multiple developmental stages of mouse early embryos.

(3) Query target genes that may be regulated by eRNAs across multiple developmental stages of mouse early embryos.

How to cite our work:

Hua Yu, Jing Zhao,Yuxuan Shen, Lu Qiao, Yuheng Liu, Guanglei Xie, Shuhui Chang, Tingying Ge, Nan Li, Ming Chen, Hu Li, Jin Zhang, and Xi Wang. Cell Reports (2024) https://doi.org/10.1016/j.celrep.2024.114077